IT and Engineer web site
In the past we faced this problem:
https://support.microsoft.com/en-us/topic/kb3186435-fix-sql-server-2016-database-mail-does-not-work-on-a-computer-that-does-not-have-the-net-framework-3-5-installed-or-stops-working-after-applying-sql-server-update-3480beb6-1329-74d6-0f3a-e8e3d893326c
This is official Microsoft KB that fix problem:
https://learn.microsoft.com/en-us/troubleshoot/sql/releases/sqlserver-2016/servicepack1-cumulativeupdate2